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2) directly, since the lung possesses an extremely large surface area for gas exchange, it is possible that gas-phase cigarette smoke components interact with plasma constituents in the interstitial fluid

You dont want a box so small that the pipe presses against the sides, but you also dont want a box so big that the pipe rattles around like a spray paint can

Products that heat a liquid solution containing nicotine, flavoring, and other chemicals into an aerosol that is inhaled by the user